CBD oil is short for cannabidiol, which is an extract of the cannabis plant, usually in the form of a wax, or infused into a spray. It’s been shown to have various calming, anti-inflammatory and anti epilepsy properties, amongst other uses.
What is CBD?
CBD oil is short for cannabidiol, which is an extract of the cannabis plant, usually in the form of a wax, or infused into a spray. It’s been shown to have various calming, antiinflammatory and anti epilepsy properties, amongst other uses.
It’s effects have been long used as part of the cannabis plant, although only in modern history has it been identified and located as an individual chemical.
Although it comes from the same plant as THC, and is similar to it in many ways, it has none of the psychoactive properties of it.
What does CBD do?:
CBD has a long history of being used for medical issues, the cannabis plant being used all the way back to Ancient China.
Various studies have been conducted, examining it’s effect on stress and anxiety, joint and inflammation pain, and even shown itself as one of the few ways to treat epilepsy that we know of.
To speak broadly on the effects, where THC directly affects the brain and calms the body and nervous system, CBD, only has the calming effect. Most people who talk about the effects say that it’s “about what you don’t feel, more than what you do feel”, referring to an alleviation of stress and pain.
THC and CBD affect the endocannabinoid system, which is a system of neurotransmitters throughout the body that regulate things like sleep, appetite, immune tissue and stress.
THC affects two different receptors, CB1, which is primarily found in the brain and CB2, which is responsible for immune system cells. THC feeds these receptors, making them get excited.
CBD however makes nullifies the CB1 and CB2 receptors, and calms the body down.
Although it doesn’t get you “high” in the same way that marijuana does, it’s still considered illegal, or at the very least highly restricted in many parts of the world, including Australia.
CBD has had many studies conducted on it’s effect on joint pain, tissues damage and nerve issues, mainly on its ability to treat these as an anti-inflammatory. Autoimmune issues that cause inflammation have shown to be somewhat treatable with the use of CBD, with fairly few side effects.
Neurodegenerative diseases, such as Alzheimers and Parkinsons have been fairly hard to treat, as the disorders literally decay the structure of the brain. What a neuroprotetive does, which this 2018 review suggests a use for CBD is, actually plays a role in protective and preserving the neurological structure of the brain, fighting against the progression of these diseases.
Generally, Epilepsy is something that’s been problematic to treat, usually most forms of treatment has so many side effects that it’s preferable to deal with the symptoms.
However, a recent study explored that when used on children, CBD reduces are large amount of seizures, 43% of participant’s seizures being cut down by more than half, while 5% actually having them gone completely.
Not only has CBD shown itself use in this area, but it’s small comparative side effects makes it largely more preferable to most other alternatives.
A big draw for marijuana is as a medication for anxiety disorder. However, due to the THC contents of it, the psychoactive traits of it cause people’s experience with it to worsen their anxiety more than anything.
CBD however, doesn’t have any of the potentially stress inducing effect of the THC, allowing users to feel relaxed, without the volatility of the psychoactivity.
Sleep is the cornerstone of both mental and bodily health, often many of bodies functions being linked to the circadian rhythm. The relaxing properties allow users to get sleep of a much higher quality by calming the body and letting it sleep, rather than other sleeping pills that emulate drowsiness to induce sleep. This can be seen in a studies done as new as 2019.
Although not as much as some medications, CBD does have some side effects.
Diarrhea, fatigue and changes in appetite and weight have been known. Others include dryness of mouth, low blood pressure, lightheadedness and drowsiness.
Although rare, there have been some signs of liver injury in use.
It has also been shown to have interactions with medications, so it’s advisable to talk to a medical professional if you’re taking anything regularly.
Melanotan 2 in the Media
Brits Buy it Cheap (Sep 2019 thesun.co.uk)
In 1998 British pharmaceutical groups began official medical trials for CBD, and in 2004 a case study of the Figi family went mainstream. This family had a little girl called Charlotte, who experienced over 300 weekly seizures, starting at the stage of 3 months. Medicine didn’t help and the only dietary treatments caused her terrible side effects, such as loss of bone and damage to her immune system. At that point, CBD wasn’t necessarily a band, but was behind so much red tape that actually acquiring it legally was long process, but after a long fight they finally managed to receive permission to use CBD to treat it.
Barbie Drug (Feb 2017 news.com.au)
Later in Australian history, a ground breaking event occurred in Australia in 2016, where we joined the group of countries allowing the use of CBD and other cannabis products for medical purposes. What may sound like a fairly small step in legislation is a huge leap towards breaking down the image of cannabis products and showing that CBD is a legitimate medicine. This was further expanded upon in a 2018 survey that looked at its users and found almost no negative effects or responses from the uses. More recently, in 2019 we actually saw a country allowing the ACT to have possession of cannabis legalised.
CBD Research Studies
Although legal restrictions have been an issue when researching CBD, recent reform has allowed it the full potential of its use to be explored.
Here’s a list of some studies that have been conducted recently looking at the effects:
One study that has shown the useful of CBD on seizures is Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. It looked at children with Dravet syndrome, a major cause of epilepsy, mostly affecting children. This is the one that’s specifically hard to treat due to both the physiological nature of a developing child, and the difficulty in treating seizures in general. This trial was double blind and placebo controlled, using 120 children. So a robust study, except for the small sample size. Over 14 weeks they were given 20mg per KG of body weight per day.
The median seizures per month decreased from 12.4, to 5.9, an incredible over 50%.
Another assessment looked at the use of Cannabis based treatments of rheumatoid arthritis; Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. It was double blind and compared with placebo and looked at 58 cases. The study showed a significant decrease in pain during rest, movement and a higher quality of sleep. While the sample size was small, the implications of this fairly new medications can be significant when helping deal with the pain of arthritis.
Melanotan 2 Anecdotal Claims
Date: April 2012
Depeche has been using melanotan for 7 years in the summer season. Hasn’t had any side effects, and one mole on the back that hasn’t changed. Likes to begin dosing at 0.250 eventually upping it to 0.500mg.
I have had 0 bad effects from it, only good ones. From beeing pale as paper, to being a nice bronze typical beach guy, no need for spf, laying on my floating bed mid ocean all day. Best feeling in the world!
Legal Status in Australia
Melanotan 2 is not included on the Australian Register of Therapeutic Goods (ARTG) and have not been assessed for quality, safety or efficacy by the TGA.
It is illegal to advertise and supply these products, and their use has proven serious side effects that can be very damaging to one’s health.
Melanotan-I (Afamelanotide) and Melanotan II are listed in Schedule 4 (prescription-only medicines) of the Poisons Standard. This means they require close regulation and monitoring by the TGA and medical authorities, and have the potential to cause harm if not used under the supervision and instruction of a health professional.
Melanotan 2 Dosage and Usage
When reconstituted with sterile water or bacteriostatic water, the melanotan 2 peptide becomes effective. Reconstituting the tanning peptide is a part of the process for use and will require full attention to get proper results. 1-2ml sterile water will reconstitute the peptides. Diluting with more volume will improve dosing accuracy. Here is a quick video demonstrating the process.
The Fitzpatrick Skin Chart
In order to fully measure the differences between fairer skin tones and darker ones, the Fitzpatrick skin type chart organizes them into one of six categories, making it easy to identify those who are at greater risk for skin cancer and make keeping track of tanning efforts easy.
|Fitzpatrick Skin Type||Description|
|I||Very fair. Always burn, never tans.|
|II||Fair skin, always burns but occasionally tans.|
|III||Medium skin, sometimes burns, always tans.|
|IV||Olive skin, rarely burns, always tans.|
|V||Modestly pigmented brown skin. Never burns.|
|VI||Definite pigment, never burns, always tans.|
Depending on the user’s skin type, dosage for a full tanning season (3 months, typically), will vary. These are the most commonly advised dosages based upon skin type according to the Fitzpatrick Scale.
Appropriate 3 month Melanotan 2 dosage after loading phase:
|I||30 to 50mg|
|II||20 to 30mg|
|III-VI||10 to 20mg|
The initial phase is typically rather small. 0.25mg is a sufficient amount to gauge how your body will react to Melanotan. To avoid any potential nausea, the dosage should be applied prior to going to sleep. Upon waking, any problems will be manifested and will be easier to treat.
Loading doses can be applied once the body has shown that it will not be adversely affected by Melanotan. A loading dose can be injected once per day and will usually consist of an amount between 0.5mg and 1mg. User feedback from this injection range is of positive results with darkening skin pigmentation. If days are missed through the loading phase, it does not require a full reset of the program which will accommodate those with travel plans or the forgetful.
Once the desired pigmentation has been acquired, maintenance doses can be attributed on a weekly basis. They are typically two to three times larger than the loading dose due to their infrequent application. A simple example shows Betty injecting 0.5mg per day, combined with a sunbed session every second day. Once her optimal pigmentation had been achieved, she began to take a maintenance dose of Melanotan once a week at 1mg per dose.
Melanotan is not a miracle skin colour changer. The body will still require exposure to UV light in order for the Melanotan to function. This can be achieved through natural sunlight or a tanning bed. It does act as an accelerant for the process so caution will need to be taken to the duration of time that the skin is exposed. Covering the body appropriately whilst deliberately tanning will ensure an even darkening of skin pigment. As a tan can unexpectedly develop, dosing should be done gradually and carefully to ensure the optimal tan is achieved..
Burning is still a serious risk despite the use of Melanotan. The peptide will not act as sunscreen, natural or otherwise, to the body. The skin should only be exposed to the sun or tanning bed for the amount of time it can handle without becoming burnt. As the skin tone begins to darken through Melanotan use, the body should gradually be able to extend the amount of time it is exposed to UV light.