You may have heard of the ibutamoren MK 677 being thrown around in the same arena as SARMs such as S-23, but the truth is that it ISN’T a SARM at all. MK 677 is a performance-enhancing drug, or PED, and works entirely differently to anabolic steroids and SARMS.
Ibutamoren MK 677 is a growth hormone (GH) stimulating drug. It works by stimulating Ghrelin hormone inside the body, specifically in the central nervous system. This in turn sends signals to your muscles to grow bigger. In fact, it was originally used as a growth hormone in children who failed to thrive.
Read on to learn more about Ibutamoren MK 677 in Australia.
What is Ibutamoren MK 677?
As bodybuilders, we have had access to a number of different performance-enhancing supplements. SARMs are a well known one, and anabolic steroids were heavily used a few years ago. MK 677, although it sounds like a machine gun, is in fact just a compound that binds to Ghrelin GH secretagogue receptors in the hypothalamus area of the brain. This in turn causes an excess in the production of growth hormone (GH) and insulin-like growth factor (IGF-1).
Both of the above hormones are responsible for limiting or increasing how your body grows. In children, this is used to help them develop further, grow taller, and develop more muscle mass. In bodybuilders, this is used to tell your muscles to grow bigger. Other great effects include an increased appetite, increased and better sleep, better injury recovery, better fat burning, and less downtime in general. Ibutamoren MK 677 was adopted into the fitness and bodybuilding world as a performance-enhancing drug as long ago as 1998. Studies have proven that males taking the drug enjoy a vastly increased muscle mass, increased performance, and increased appetite without the potentially bad side effects of either anabolic steroids or SARMs.
How Does Ibutamoren MK 677 Work?
MK 677 is also known as ibutamoren. It is a secretagogue of growth-stimulating hormone and has been shown both in-vitro and in-vivo to be basically indistinguishable from peptide HGH secretagogue GHRP-6. Known as a nonpeptide spiropiperidine, it has been used to great effect in stimulating growth in both children and adults. It not only promotes increased muscle mass but also liner growth as well as bone density and injury recovery.
Ibutamoren works pretty simply by stimulating the hormone ghrelin. Ghrelin is produced in the stomach, and bonds with Ghrelin receptors (GHSR) in the brain. This hormone is also known as the hunger hormone, as it stimulates appetite and growth. When this hormone is given to humans, it can stimulate appetite up to 30%. This change happens in the hypothalamus area of the brain, which is responsible for body temperature, appetite, and hormone release among other things. It sits at the front of the brain just near the pituitary glands above the eyes.
Once the Ghrelin has been stimulated, it is taken up by the Ghrelin receptors in the hypothalamus. These tell the body to increase appetite, and in turn, grow more. Once this process has been initiated, muscle mass increases, linear growth is stimulated where possible, and healing is turbocharged. Ibutamoren MK 677 works in exactly the same way as ghrelin and can be classed as a synthetic version of the natural hormone.
MK 677 in the Media
Anti-frailty Pill For Seniors (Nov 2008 sciencedaily.com)
Date: November 05, 2008
A respected scientific online publication, Science Daily, takes a look at a new drug with growing potential to prevent frailty in seniors. The drug, MK 677, has been shown to increase muscle mass as well as bone density with few negative side effects.
The article explores a study done in 2008 whereby a number of people ranging from 60 to 81 years of age were given the drug. The study was a double-blind, placebo-controlled event conducted by the University of Virginia. The doctor in charge, Doctor Thorn was quoted as saying: “The UVA research was a “proof-of-concept” study that sets the stage for a larger and longer clinical trial to determine whether MK-677 is effective in people who are frail and to assess its long term safety”
Growth Hormone Seniors Muscles (Nov 2008 webmd.com)
Date: November 03, 2008
Another article on the study done regarding MK 677 Ibutamoren and the increased muscle mass in seniors. This article goes a bit more in-depth, showing how both the body weight, and aging process were affected. The participants of the study, ranging from the ages of 60 to 81, showed a marked increase in muscle mass and a marked decrease in the aging process.
The doctor in charge, Michael Thorner, MB, BS, DSc, and Ralf Nass, MD, were pleased by the results that he saw from MK -677. They said that they saw an increase in blood pressure, although very slight, and a decrease in insulin sensitivity. The article is a positive one for MK 677, showing that the drug has good effects on all sorts of people, without many of the nasty side effects often associated with muscle building enhancement drugs.
Ibutamoren Clinical Collaboration (May 2022 globenewswire.com)
Date: May 05, 2022
This article declares that a new partnership between Lumos Pharma and Massachusetts General Hospital will be investigating the effects of ibutamoren on patients with Nonalcoholic Fatty Liver Disease (NAFLD). The Food and Drug Administration has approved this study which will see a 6 month trial study in 10 men and women to be administered with a daily dose of ibutamoren. The primary focus will be in determining how with growth hormone augmentation impacts changes in both intrahepatic lipid content and hepatic inflammation and fibrosis. In short, preventing NAFLD progression.
Ibutamoren – Research Studies
Reverse Diet-Induced Catabolism
MK 677 was used in a study to find out the effect of growth hormone on Diet-Induced Catabolic patients. A double-blind, randomized, placebo-controlled, two-period cross-over study was conducted on a group of 8 healthy humans aged 24 to 31 years. Their caloric intake was reduced to 18 kcal/kg.day for a two week period. During that time. All 8 people lost substantial weight and muscle mass. For the last week of the project, each subject was given a pill which was either a 25mg MK 677 or a placebo.
Those that were given the real dosage of MK 677 showed a marked improvement. This was determined to be due to the it’s reversing diet-induced nitrogen wasting. It was determined the MK 677 would be useful in patients who were catabolic due to various acute or chronic disease states.
Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults (MOT089)
Another human trial, this time to test whether the application of MK 677 or synthetic Growth hormone, would have an effect on GH release and IGF-I concentrations. 65 humans between the ages of 60 and 81 were chosen for this two-year, double-blind, randomized, placebo-controlled, modified-crossover clinical trial.
This study was to determine the effect the MK 677 had on aging. The study consisted of two groups of people, both of whom were taking a dosage of a drug every day. One group was taking a placebo, the other was talking MK 677. The results showed that those who were taking the MK 677 did so without any significant side effects. The drug did, however, increase bone density and keep muscle strength from deteriorating. The placebo group was shown to have a marked muscle deterioration over the 24 month period, while the MK 677 group did not.
The use of Ibutamoren for the treatment of hip fracture
This study investigated the impacts that the application of ibutamoren had on elderly patients recovering from a hip fracture. A double blind study of 123 elderly patients were given the dose of 25mg/day or a placebo. Primary outcomes of the study were a rank in the functional performance measurement and the blood levels of insulin like growth factor-1.
MK 677 – Anecdotal Evidence
Date: Aug 30, 2019
Reviewed on a bodybuilding site, MK 677 was found to have very positive results. Reddit users have reported a huge increase in muscle mass and fat loss after taking Ibutomoren, or MK 677. They say that although it is a slow-acting compound, unlike a SARM, once it does begin to work the results are fantastic.
It can be stacked with other performance-enhancing drugs such as S-23. S-23 is one of the strongest SARMs on the market. When stacking MK 677 with a SARM, one should do careful research to ensure the correct dosage. An example of both a cutting and a bulking stack could be:
|Sample Bulking Stack||Sample Cutting Stack|
|MK 677 – 50 mg per day||MK 677 – 25 mg per day|
|RAD 140 – 15 mg per day||Ostarine – 25 mg per day|
|YK11 – 10 mg per day||Andarine – 50 mg per day|
It was noted that in the correct dosage, MK 677 does not affect growth hormone too much, but does have a significant effect on IGF-1. As much as 10 to 15 pounds have been claimed on a simple 12-week cycle of MK 677.
Date: Apr 13, 2010
Reviewer aphextwin only has positives to say about MK677
“Mk is the shit. I love it. I have been only using 12.5 mg about 30 minutes prior to retiring for the night. I swear the sleep is incredible too. I always wake up feeling very rested…”
Date: Dec 11, 2016
neotuur asked the forum about MK677 in relation to impacts upon sex drive and received a number of responses.
dylangemelli responds that MK677 does not have suppressive effects. They do warn that it can be difficult to locate a reliable supplier as it is commonly counterfeited with inferior substances.
user rickrock confirms that MK677 isn’t suppressive. They indicate that using MK677 will help achieve results in the gym but perhaps there are other factors that they need to be considering such as nutrition
Is MK 677 Legal in Australia?
MK 677 is considered a schedule 4 prescription drug. That means that it is accessible with a doctor’s prescriptions. Otherwise, it is not legal to buy MK 677 in Australia. This is due to the fact that it has extensive human trials.
One can buy MK 677 on the internet from a variety of shops both local to Australia and international.
Buy MK 677 in Australia
There are numerous places where you can buy ibutamoren MK 677 in Australia.
Bear Supplements (30mg)
Australian based company selling a modified version of MK677 that is legal to purchase.
MK 677 Dosage & How to Use?
MK 677 Ibutamoren has few side effects, although the higher you dose the more likely you are to encounter adverse results. Dosages will vary depending on what you wish to achieve. For example, if you just want to counter the effects of aging, you will take a much lower dosage than if you want to bulk muscle and slash fat. A good example of a recommended MK 677 dosage is:
- 25mg per day for bodybuilding purposes.
- 20mg per day for fat loss purposes
- 10-20mg per day to heal an injury such as a broken leg.
- 10-20mg per day for anti-aging purposes.
Most bottles contain 10mg capsules. If you buy the powder, then you can mix it with protein shakes and alter your dosage. Be aware when using the powder that you will have to weigh it accurately to get the correct dosage.
Stacking MK 677 and SARMs
Stacking MK 677 and a SARM such as S-23 is another popular way to take Ibutamoren. This increases the muscle building and fat shredding capabilities but does add side effects that one wouldn’t get with it alone. It has a half-life of 24 hours, which means that you can take one dose a day. Most SARMs need to be taken twice a day. The best stacks of SARMs and MK 677 include combining with Ostarine or Cardarine for cutting, and Ligandrol or RAD 140 for bulking.