Selective Androgen Receptor Modulators (SARMs) have been in clinical test trial phases for over 10 years at this stage. The medical industry is particularly interested in the very targeted effects that are being further explored.
As an anabolic type of drug, the main targeted areas are the triggering of growth hormone (GH) in very specific places in the body. Unlike traditional hormone treatments that result in GH being released everywhere, SARMs aim to only trigger those areas where it produces positive physiological reactions.
This means there are far less and in some cases no known side effects.
2 of the main target areas are bone and muscle tissue production for dealing with effects of disease or natural ageing processes. During many clinical test trials, there have been some further discoveries of very positive effects.
One such effect is the increased burning of body fat as a source of energy for increasing bone and muscle tissue. This is leading some scientists to explore SARMs as a treatment option for obesity.
First, let’s take a look at how the fat reduction is triggered.
What Affects Fat Reduction
Every diet on earth aims to reduce the amount of energy intake to force the body to retrieve energy from stored body fat. The physiological process to trigger this, can sometimes takes weeks and even months to fully start showing effects.
The reason is that the body has become used to a steady source of very easily accessible energy in blood sugar levels.
Generally speaking a mixture of diet and exercise will force the body to reduce body fat. But SARMs are showing some very positive signs of speeding up that process.
All physiological reactions in the body require energy. Synthesising new cells is particularly energy intensive, especially when it comes to building up new muscle fibres. The most readily available energy is stored just under the skin and in muscles themselves in the form of fat.
It’s precisely this unwanted fat that SARMs are triggering as a source of energy.
What Studies Have Shown
Over the past 10 years a lot of different SARMs have been developed that have gone through various stages of clinical trials. Because these drugs are still so new, full approval has not yet been achieved. But there is substantial interest in the medical industry to further develop and test them.
In this section we will show some results that have come out of 3 research studies that have been published since 2008. These show the very positive impacts with various different conditions for the drugs to be used in.
Study 1 Results
The Boston University School of Medicine conducted a research study that aimed at collecting all the findings from clinical trials in one place. The basis for the study was the indication that numerous clinical trials have revealed significant anabolic applications for synthetic SARMs.
The study analysed data from numerous clinical trials and showed that specifically bone density increased and muscle fibre production were found in all studies conducted on various different drugs.
The added benefit that most studies also reported was a modest reduction in body fat stored in muscles and under the skin, mainly around the abdomen. However, what none of the studies were able to clearly identify is what exactly was triggering this fat loss.
This is precisely what the study suggests needs to happen in further clinical trials. A better understanding of the selectiveness and the exact processes that are triggered will be required in order to progress SARMs further. Phase I and II trials have been well documented, but to bridge the regulatory hurdles, studies will have to cover those gaps understanding.
Study 2 Results
The next study was conducted by Preclinical Research and Development, GTx, Inc and aimed at summarising all the known positive and negative side effects from SARMs. Compared to the above study, the authors aimed at identifying more of the known physiological triggers that have been observed.
Because the current research information and trials had already provided a proof of effects, it was more important to focus attention on the “Why” not the “What”. The result is a very detailed research paper that does provide a lot of information about what happens in the body.
The paper especially highlights the bone density improvements, build-up of muscle tissue and a marked decrease in stored body fat. One study result from elderly men showed a definitive decrease in fat within 3 months of the trial.
The authors also go to great extent to show test results from some of the biggest pharmaceutical companies in the world. These all showed how effective different synthetic drugs were at triggering muscles and bones, without any severe side effects.
Study 3 Results
The final study of interest was published by the College of Pharmacy, Ohio State University, which specifically looked at using SARMs to enhance female sex drive. This loss of sex drive is mainly triggered by menopause. /The study aimed at observing how SARMs may be developed to treat these and other effects of menopause.
First, the researchers looked at the results of hormone treatment using Testosterone on pre and post-menopausal women. The results were all positive, but long-term use of testosterone and in some cases short term as well, are not advisable.
As far as fat loss is concerned, the authors highlight several studies that showed improvements in fat mass and lean muscles. These were observed in both human and animal trials to varying degrees. But all proved significant improvements that cannot be ignored and warrant further testing.
SARMS are an exceptionally promising drug that are likely to provide huge benefits in many different treatments. The almost lack of any side effects and ability to focus their binding in very specific places of the body are what is drawing in much of the attention.
Unlike older hormone treatments, far more selective and long term treatments look likely to be possible. One such area of interest is treatment of obesity by causing anabolic reactions that result in more effective fat burning.