Andarine or S4 as it’s commonly known, is one of the many selective androgen receptor modulators – SARM. It primarily helps increase muscle while reducing fat.
S4 SARM was first synthesized by GTx Pharmaceuticals to treat muscle wasting issues. Though the drug hasn’t been FDA approved for humans, bodybuilders use it to increase their muscle and reduce fat.
Read on to learn more about its benefits, dosages, working, anecdote, and clinical research in this ultimate Andarine S4 Review.
What is Andarine S4?
Andarine S4 or S4 SARM is a supplement that activates protein-synthesizing genes by binding to androgen receptors. Protein is a fundamental muscle building block, so the action helps with muscle repair and production.
This, however, is achieved through selective expression of genes. Of all the selective androgen receptor modulators – SARMs available, S4 is the most powerful.
It not only increases lean body mass but also preserves it.
The best and quickest way to achieve results is by mixing the powder with biostatic water and then injecting it. Andarine is orally bio-available with a strong anabolic effect encouraging lean muscle growth in the body.
Benefits & Side Effects Of S4 SARM
Andarine selectively binds to the body’s skeletal muscle androgen receptors to exert a strong anabolic effect. In the process, it encourages lean muscle growth, quick fat loss, and improved athletic performance.
S4 SARM is thus popular with bodybuilders for its strong anabolic effects that help with cutting. Users report achieving ‘cut and dry’ looks in three months.
However, unlike other SARMs, S4 is more selective in the actions triggered. In turn, it reduces potential side effects while permitting specific applications to improve muscle and bone density.
It also enhances the body’s overall stamina and strength.
In short, S4 focuses on your body recomposition. It helps increase muscle fiber production while reducing body fat. It shows maximum improvements in ‘skinny fat’ people with lots of fat but minimal muscle mass.
The body’s bone density tends to fluctuate and reduce with age due to certain medical conditions. S4 helps here by improving bone density by restricting the effects of osteoporosis.
S4’s primary benefit lies in helping users build lean and dense muscle, and for cutting. It also helps enhance your gym recovery time.
While people generally need 72 hours to recover, the recovery time reduces to 24 hours with Andarine. So you can get back to gymming faster and train more to experience better and quicker muscle and strength gains.
However, the results mainly depend on how hard you train and your diet during the cycle.
S4 SARM in the Media
Workout supplements health risks (Dec 2019 newswire.ca)
According to Newswire, Health Canada considers S4 SARM to be an unauthorized workout supplement because it can trigger various health risks. Canadians are advised against taking these compounds, where many have been seized from the retail location.
DRS-Labs Research (Aug 2018 markets.businessinsider.com)
According to Business Insider, DRS-Labs announce new research on SARMs to provide researchers with a new way to administer them. Most SARMs comprise of subcutaneous or skin-delivery formulations which trigger varying and low blood level fluctuations hours after administration.
While skin patches facilitate better blood level fluctuations; it can trigger skin irritations.
DRS-Labs thus decided to launch a tailored solution through organic-pressed tablets and capsules. Targeted tissues tend to respond as they should to androgens, while tissues that usually exhibit side effects no longer do.
The products are in the research phase, but lots of communities are excited and speaking about it.
Andarine S4 Research Studies
Relation with fracture reduction
A study was conducted to examine S4 effects on the bone and body through an ovariectomy-induced model of accelerated bone loss. It was performed on rats where S4 treatment was started immediately after ovariectomy and continued for four months.
S4 helped maintain the whole body and trabecular BMD, increased bone strength, and reduced the rats’ body fat.
The data thus showed S4’s protective skeletal effects, and that it could help reduce fractures. This fracture reduction approach proves to be advantageous over other existing therapies.
Pharmacodynamics of SARM
A study was conducted to identify SARMs in vivo pharmacological activity. Four chiral, nonsteroidal SARMs were synthesized, and it’s in vitro and in vivo pharmacological activities were examined.
The compounds exhibited high androgen receptor (AR) binding affinity in vitro assays. Three compounds stimulated AR-mediated reporter gene expressions.
The compounds were then subcutaneously administered to castrated rats, and there in vivo pharmacological activity was appraised.
S1 and S4 exhibited in vivo androgenic and anabolic activity while S2 and S3 didn’t. S1 and S4 stimulated anabolic organs more than androgenic organs.
So S1 and S4 were identified as potent and tissue-selective SARMs in vivo pharmacological activity. They represent the first few SARMs with selective anabolic effects.
Russolifts was pretty happy with his S4 results. He gained about 5lbs of muscles on his S4 cycle comprising of 50mg of Andarine a day for eight weeks.
The best thing was that he managed to keep this strength gain because he continued training hard even after the cycle ended.
He also lost about 4% of body fat. It is why he recommends the S4 SARM for anyone who wants to lose fat and gain muscle simultaneously. Of course, he once again reminds us that the results all depend on your diet and training.
Source : evolutionary.org
Date : May, 2014
BigMarti also acknowledges substantial results in muscle growth and good strength increase with his S4 cycle. But he was recovering much faster than before, even after working out a complete HIT style two days in a row.
He started maxing dosage at 50mg/day while doing five days on and two days off. That’s when he noticed some vision side effects.
However, it was rectified by taking two days off and lowering his S4 dose. He tried switching to 6/1 and noticed the vision sides were much less. So while vision problems are a significant side effect, it can be reduced by lowering the dosage and taking two days off.
As long as you control your dosage, you can enjoy the results of increased strength, stamina, and muscle S4 SARM offers!
Is S4 SARM Legal in Australia?
Australia has different laws about SARMs when compared to the rest of the world. Selling and supplying SARMs in Australia is a serious offense if done without the right permission.
Andarine S4 consumption is also illegal if consumed without a doctor’s prescription. It’s because it’s not FDA approved yet.
But many people still buy and use S4 SARM without a doctor’s prescription.
Practically all sports bodies ban Andarine, including the ADADA (Australian
Sports Anti-Doping Authority). Professional athletes are prohibited from taking it because of the unfair muscle mass and strength advantages it provides.
The regular supplement stores and gyms may not be permitted to sell S4 SARM. But there are a few companies that legally import SARMs into Australia. It’s safe to buy from them.
S4 SARM Dosage & Usage
There is so far no established therapeutic medical S4 dosage. Most users are comfortable taking 25-100mg dosage per day. As the effects depend on the dosage, you can expect better results by increasing your S4 SARM dosage.
However, it’s accompanied by increased side effects too.
The ideal S4 Andarine beginner dosage is 25mg a day; the intermediate dosage is 50mg a day, and the advanced dose is 100mg per day.
With Andarine having an 8-hour half-life, most people split their dosage throughout the day.
It helps maintain an even blood concentration.
If you split the dosage in two, take the first dose early in the morning and the second dose before bed.
Splitting S4 dosage into three is however even better.
You can take the first dosage in the morning, second during lunch, and third before going to bed. The best cycle spans a maximum of 8-12 weeks.
Bulking and Cutting Stacks
It’s also used in bulking stacks to help you stay lean and prevent fat spillovers.
A typical bulking stack involves 25mg of Andarine, 20 mg of Ligandrol, and 10mg of YK11 per day.
A typical cutting stack comprises 50mg of Andarine, 20mg of Cardarine, and 25mg of Ostarine per day.
Post Cycle Therapy (PCT)
You don’t need a PCT with Andarine because it’s not that suppressive.
It means your body recovers naturally in a few weeks after the cycle is over.
With PCT giving severe side effects, don’t do it just because someone else is doing it.
In conclusion, S4 is an excellent SARM that effectively increases your body muscle mass.
It also helps induce fat loss, reduces recovery times, and promotes strength
gain. There is one worrying side effect of impaired vision, but it isn’t permanent. It occurs with overdosing but will disappear once the cycle is over.